Dann was born and raised in Music City to a musically gifted family. His brother, David began playing drums in third grade and his father Ronn Huff was a sought-after arranger on the cutting edge of Nashville's contemporary Christian music scene. As a youngster Dann would accompany him to sessions and to this day cites his father as his first influence. Huff started playing guitar at the age of 9. He took a few lessons, even classical, but played mostly by ear. When he was 13, a session guitarist by the name of John Darnall taught him his first scale, and that set the young Dann Huff on the career path he followed.

According to Hoyle, Dann Huff literally played on at least one track with almost every recording artist in the 1980s, as well as most of Nashville's releases in the 1990s. His sessions resume includes Barbra Streisand, Kenney Loggins, Reba McEntire, Celine Dion, DC Talk, Shania Twain, Michael Bolton, Luther Vandross, Peter Cetera, Donna Summer, Rod Stewart, Michael Jackson, Madonna, Whitney Houston, Amy Grant, Fine Young Cannibals, Barry Manilow, The Temptations, Chaka Khan, O'Jays, Smokey Robinson, Clint Black, Faith Hill, Tim McGraw, Whitesnake, Natalie Cole, Gladis Knight, Neville Brothers, Dusty Springfield, Rick Springfield, Olivia Newton-John, Toby Keith, Billy Joel, Joe Cocker, Bryan Ferry, Peter Wolf, Martina McBride, Chicago, Wynonna, Glen Campbell, Paula Abdul, Tammy Wynette, Mariah Carey, Merle Haggard, Bob Seger, Boz Scaggs and countless others.

Huff's move into production was the result of friendly persuasion by Mutt Lange, who told Huff, "You are a producer in guitarist's clothes." He was flattered but didn't know where to start until Lange recommended Huff to Faith Hill. Within a couple of years, Dann Huff was making a name for himself as a producer in Nashville. His credits included Faith Hill, Lonestar and newcomers SHeDaisy, as well as two Megadeth albums. What he couldn't have predicted was that Lonestar and SHeDaisy would become award-winning acts selling millions of albums. As their careers took off, so did his. Today, Dann ranks among Music Row's most in-demand producers, with an impressive production discography that includes Keith Urban, Rascal Flatts, Faith Hill, Lonestar, Carrie Underwood, Jewel, Wynonna, Deana Carter, Pat Green, Billy Ray Cyrus, Jimmy Wayne, Shedaisy, Kenny Rogers, Leann Rimes, Martina McBride, Bryan White, Chely Wright, Rebecca St. James, Collin Raye, Trace Adkin, Julianne Hough, Steel Magnolia, Bon Jovi and Steven Tyler, just to name a few

Some of Dann's 'cherished awards' include: 2012 ACM Producer of the Year, 2010 ACM Producer of the Year, 2006 ACM Producer of the Year, 2006 MUSIC ROW AWARDS Producer of the Year, 2004 CMA Musician of the Year and 2001 CMA Musician of the Year.